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Drug Development and Industrial Pharmacy Volume 25, 1999 - Issue 8
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Research Article

In Vitro Release Behavior of Toremifene Citrate from Sol-Gel Processed Sintered Silica Xerogels

Manja Ahola,Pirjo Kortesuo,Ilkka Kangasniemi,Juha Kiesvaara &Antti Yli-Urpo
Pages 955-959 | Published online: 26 Jul 1999
 
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Abstract

Factors affecting the adsorption and desorption of toremifene citrate (TC) on sintered silica xerogels were investigated in vitro. TC was attached onto sol-gel processed sintered silica xerogel grains or disks by adsorption. The adsorption of TC on the surface of silica was pH dependent. The results support the conclusion that large pore size results in highest drug adsorption. Adsorption of TC was most effective in xerogels sintered at 700°C and containing the largest pores and lowest specific surface area of the silica xerogels studied in the adsorption tests. The release of TC from the xerogel matrix was linear with respect to the square root of time. The release of TC from the grains was very rapid for the first 5 hr, followed by a slower release. All drug was released from the grains, and 60% to 80% was released from the disks in 24 hr. All drug-silica xerogel formulations showed sustained in vitro release profiles.

 
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